Bioluminescent probe for detecting endogenous hypochlorite in living mice

文献情報

出版日 2017-12-19

DOI 10.1039/C7OB02842C

インパクトファクター 3.876

著者

Chunchao Tang, Yuqi Gao, Tingting Liu, Yuxing Lin, Xiaomeng Zhang, Chaochao Zhang, Xiang Li, Tianchao Zhang, Lupei Du

原文を見る

要旨

As a kind of biologically important reactive oxygen species (ROS), hypochlorite (ClO−) plays a crucial role in many physiological processes. As such, endogenous ClO− is a powerful antibacterial agent during pathogen invasion. Nonetheless, excessive endogenous ClO− could pose a health threat to mammalian animals including humans. However, the detection of endogenous ClO− by bioluminescence probes in vivo remains a considerable challenge. Herein, based on a caged strategy, we developed a turn-on bioluminescent probe 1 for the highly selective detection of ClO−in vitro and imaging endogenous ClO− in a mouse inflammation model. We anticipate that such a probe could help us understand the role of endogenous ClO− in a variety of physiological and pathological processes.

掲載誌

Organic & Biomolecular Chemistry

CiteScore: 3.4

自己引用率: 10.3%

年間論文数: 1041

Organic & Biomolecular Chemistry (OBC) publishes original and high impact research and reviews in organic chemistry. We welcome research that shows new or significantly improved protocols or methodologies in total synthesis, synthetic methodology or physical and theoretical organic chemistry as well as research that shows a significant advance in the organic chemistry or molecular design aspects of chemical biology, catalysis, supramolecular and macromolecular chemistry, theoretical chemistry, mechanism-oriented physical organic chemistry, medicinal chemistry or natural products. Articles published in the journal should report new work which makes a highly-significant impact in the field. Routine and incremental work is generally not suitable for publication in the journal. More details about key areas of our scope are below. In all cases authors should include in their article clear rationale for why their research has been carried out.

Bioluminescent probe for detecting endogenous hypochlorite in living mice

文献情報

おすすめジャーナル

関連文献

Effect of doped zinc species on the photocatalytic activity of gallium oxide for hydrogen production

Design of energy band alignment at the Zn1−xMgxO/Cu(In,Ga)Se2 interface for Cd-free Cu(In,Ga)Se2 solar cells

Front cover

Tuning the band gaps and work functions via topology and carbon concentration: a first-principles investigation of Cx(BN)y compounds

Operando DRIFTS study of the redox and catalytic properties of CuO/Ce1−xTbxO2−δ (x = 0–0.5) catalysts: evidence of an induction step during CO oxidation

Iron phthalocyanine coated on single-walled carbon nanotubes composite for the oxygen reduction reaction in alkaline media

A rotating disk electrode study of the particle size effects of Pt for the hydrogen oxidation reaction

Reversible transient hydrogenstorage in a fuelcell–supercapacitor hybrid device

An innovative computational comparison of exact and centrifugal sudden quantum properties of the N + N2 reaction

Intermolecular acetaldehyde and dimethoxymethane formation mechanisms viaethenol and methoxymethylene precursors in reactions of atomic carbon with methanol: a computational study

こちらもおすすめ

カルボニル基が付いた5-氰基-1-{[(2-メチル-2-プロpanyl)オキシ]カーボンイル}1H-吲哚-2-イリド-2-ボリン酸はどのように保存すればよいですか？

tert-ブチル2-クロロメチルピリジン-3-基炭酸エステルの市場動向や研究トレンドはどうですか？

聚二季戊四醇六丙烯酸酯はどの業界で使用されていますか？

1-氯-5-硝基异喹啉の市場動向や研究トレンドはどうですか？

2-チロール-5-メチルスルフェニル-3-trifルオルメチルベンゼンはどのように合成されますか？

p-トールイルマグネシウムブロミドの物理化学的性質は何ですか？

1-(5-甲基-2-硫化素基)プロパン-1-酮の市場動向や研究トレンドはどうですか？

十一碳烯酰甘氨酸を取り扱う際の実験室安全事項は何ですか？

1H,1H-全氟-3,6-二氧杂葵-1-醇を取り扱う際の実験室安全事項は何ですか？

3-(4-(フルオロメチルオキシ)フェニル)-1,2,4-オキサジアゾール-5-カルボハイドライドは安全ですか？

掲載誌

Organic & Biomolecular Chemistry

おすすめ化合物

N-[(6-Bromo-3-pyridinyl)methyl]ethanamine

4-Butoxy-2-chlorobenzoic acid

methyl 6-bromo-3-formyl-1H-indole-4-carboxylate

4,4-Difluoro-2-methyl-1-{[(2-methyl-2-propanyl)oxy]carbonyl}-L-proline

2-Methyl-3-pyridinesulfonyl chloride

おすすめサプライヤー