Pd-Catalyzed one-pot sequential cross-coupling reactions of tetrabromothiophene

文献情報

出版日 2017-11-17

DOI 10.1039/C7OB02601C

インパクトファクター 3.876

著者

Kapil Mohan Saini, Rakesh K. Saunthwal, Akhilesh K. Verma

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要旨

Unsymmetrical one-pot sequential cross-coupling reactions of sterically hindered tetrabromothiophene with arylboronic acid and an alkyne/alkene to afford selective bi-, tri-, and tetrasubstituted aryl/alkynyl-thiophenes with the aid of a palladium catalyst were described. The reaction proceeds via a site-selective Suzuki/Sonogashira coupling, followed by selective Sonogashira, Suzuki and Heck coupling reactions. This methodology has demonstrated an important framework for the synthesis of organic scaffolds.

掲載誌

Organic & Biomolecular Chemistry

CiteScore: 3.4

自己引用率: 10.3%

年間論文数: 1041

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