Synthesis and biological applications of fluoro-modified nucleic acids

文献情報

出版日 2017-10-17

DOI 10.1039/C7OB02094E

インパクトファクター 3.876

著者

Fengmin Guo, Qiang Li

原文を見る

要旨

Owing to the unique physical properties of a fluorine atom, incorporating fluoro-modifications into nucleic acids offers striking biophysical and biochemical features, and thus significantly extends the breadth and depth of biological applications of nucleic acids. In this review, fluoro-modified nucleic acids that have been synthesized through either solid phase synthesis or the enzymatic approach are briefly summarised, followed by a section describing their biomedical applications in nucleic acid-based therapeutics, 18F PET imaging and mechanistic studies of DNA modifying enzymes. In the last part, the utility of 19F NMR and MRI for probing the structure, dynamics and molecular interactions of fluorinated nucleic acids is reviewed.

掲載誌

Organic & Biomolecular Chemistry

CiteScore: 3.4

自己引用率: 10.3%

年間論文数: 1041

Organic & Biomolecular Chemistry (OBC) publishes original and high impact research and reviews in organic chemistry. We welcome research that shows new or significantly improved protocols or methodologies in total synthesis, synthetic methodology or physical and theoretical organic chemistry as well as research that shows a significant advance in the organic chemistry or molecular design aspects of chemical biology, catalysis, supramolecular and macromolecular chemistry, theoretical chemistry, mechanism-oriented physical organic chemistry, medicinal chemistry or natural products. Articles published in the journal should report new work which makes a highly-significant impact in the field. Routine and incremental work is generally not suitable for publication in the journal. More details about key areas of our scope are below. In all cases authors should include in their article clear rationale for why their research has been carried out.

Synthesis and biological applications of fluoro-modified nucleic acids

文献情報

おすすめジャーナル

関連文献

Kink energy and kink dipole moments on vicinal Au(001) in halide electrolytes

Understanding the chemical dynamics of the reactions of dicarbon with 1-butyne, 2-butyne, and 1,2-butadiene – toward the formation of resonantly stabilized free radicals

Constructing a mixed π-conjugated bridge to effectively enhance the nonlinear optical response in the Möbius cyclacene-based systems

Redox hydrogels with adjusted redox potential for improved efficiency in Z-scheme inspired biophotovoltaic cells

Effect of ozone exposure on the electrical characteristics of high-purity, large-diameter semiconducting carbon nanotubes

Concentration dependence of hydration water in a model peptide

A new interpretation of SAXS peaks in sulfonated poly(ether ether ketone) (sPEEK) membranes for fuel cells

Computational investigations on the catalytic mechanism of maleate isomerase: the role of the active site cysteine residues

Water oxidation by manganese oxides formed from tetranuclear precursor complexes: the influence of phosphate on structure and activity

Long-term self-assembly of inorganic layered materials influenced by the local states of the interlayer cations

こちらもおすすめ

2-氟-4-イオドベンzo酸エチルエステルを取り扱う際の実験室安全事項は何ですか？

血根碱の主な用途は何ですか？

Methyl 3-methoxythiophene-2-carboxylateの主な用途は何ですか？

丹磺酰-L-亮氨酸はどのように保存すればよいですか？

5-(苄氧基)ピラミジン-4-アミンの代替品はありますか？

8-ヒドロキシノルデコペントアセートの物理化学的性質は何ですか？

tert-ブチル(エス)-1-ヒドロキシペンタ-4-エン-2-イルカルバamateの主な用途は何ですか？

ブコール-L-2-フローヨルブリンについて適切な法規ガイドラインは何ですか？

6-ブロモ-N-環丙基-2-ピリジニニメタンの市場動向や研究トレンドはどうですか

RS-AMPÀはどのように保存すればよいですか？

掲載誌

Organic & Biomolecular Chemistry

おすすめ化合物

1-(Hexyloxy)hexane

(2-Ethylphenyl)hydrazine hydrochloride (1:1)

3,5-Dihydroxy-4-(3-methylbutanoyl)-2,6,6-tris(3-methyl-2-buten-1-yl)-2,4-cyclohexadien-1-one

Fluifort

Phosphonic dichloride, P,P'-methylenebis-

おすすめサプライヤー