The role of amino acid side chains in stabilizing dipeptides: the laser ablation Fourier transform microwave spectrum of Ac-Val-NH2
文献情報
I. León, E. R. Alonso, S. Mata, C. Cabezas, M. A. Rodríguez, J.-U. Grabow, J. L. Alonso
The steric effects imposed by the isopropyl group of valine in the conformational stabilization of the capped dipeptide N-acetyl-L-valinamide (Ac-Val-NH2) have been studied by laser ablation molecular beam Fourier transform microwave (LA-MB-FTMW) spectroscopy. The rotational and quadrupole coupling constants of the two 14N nuclei determined in this work show that this dipeptide exists as a mixture of C7 and C5 conformers in the supersonic expansion. The conformers are stabilized by a CO⋯H–N intramolecular hydrogen bond closing a seven- or a five-membered ring, respectively. The observation of both conformers is in good agreement with previous results on the related dipeptides containing different residues, confirming that the polarity/non-polarity of the side chains of the amino acid is responsible for the conformational locking/unlocking. The voluminous isopropyl group is not able to prevent the less stable C5 conformer from forming but it destabilizes the CO⋯H–N interaction.
関連文献
Solvent-driven swelling and shrinking of poly(NIPAM) gels crosslinked by tris-methacrylated phloroglucinol derivatives
Toshio Itahara, Takahiro Tsuchida, Mayumi Morimoto
DOI: 10.1039/C0PY00068J
Connection of polymer chains using diepoxide in CO2/propylene oxide copolymerizations
Anish Cyriac, Sang Hwan Lee, Bun Yeoul Lee
DOI: 10.1039/C0PY00365D
Effect of solvents on polymerization of N-propargylamide monomer and secondary structure of polymer
DOI: 10.1039/C0PY00116C
Specific interaction of DNA-functionalized polymer colloids
Rungsima Chollakup, Wirasak Smitthipong, Arkadiusz Chworos
DOI: 10.1039/B9PY00290A
Characterization of network structure in radiation-cured resins of polyfunctional acrylic ester and N-vinylpyrrolidone by MALDI-MS combined with supercritical methanolysis
Hideki Matsubara, Hiroyasu Kataoka, Hajime Ohtani
DOI: 10.1039/C0PY00026D
Local conformation of poly(methyl methacrylate) at nitrogen and water interfaces
Yohei Tateishi, Naoki Kai, Hidenori Noguchi, Kohei Uosaki, Toshihiko Nagamura, Keiji Tanaka
DOI: 10.1039/B9PY00227H
Poly(urethane/malonamide) dendritic structures featuring blocked/deblocked isocyanate units
Yung-Chung Chen, Wen-Yi Wu, Tzong-Yuan Juang, Shenghong A. Dai, Wen-Chiung Su, Ying-Ling Liu, Rong-Ho Lee, Ru-Jong Jeng
DOI: 10.1039/C0PY00358A
Size-controlled synthesis of dendrimer-stabilized silver nanoparticles for X-ray computed tomography imaging applications
Han Wang, Rui Guo, Xueyan Cao, Jinglong Zhao, Yu Luo, Mingwu Shen, Guixiang Zhang
DOI: 10.1039/C0PY00218F
Copolymers from benzodithiophene and benzotriazole: synthesis and photovoltaic applications
Zhenhua Zhang, Bo Liu, Chunyue Pan, Yongfang Li, Yuehui He, Kechao Zhou, Yingping Zou
DOI: 10.1039/C0PY00136H
こちらもおすすめ
3-(2-オキサプロピル)ベンzoic酸はどのように合成されますか?
3-(2-オキサプロピル)ベンzoic酸は、ベンzoic酸とプロパノ酸をヒドロキシム化合物として反応させて生成します。具体的には、ベンzoic酸とプロパノ酸を反...
4-メチル-4-ピペリジニル-1-ピロリドイン甲酸の主な用途は何ですか?
4-メチル-4-ピペリジニル-1-ピロリドイン甲酸は、主に医薬品の合成材料や研究用物質として使用されます。さらに、一部の薬理学的研究にも応用されています。
Biotin-PEG3-oxyamine HCl塩について、適切な化合物名称に適用される法規ガイドラインは何ですか?
Biotin-PEG3-oxyamine HCl塩は、GHS( Globally Harmonized System of Classification and...
N-(4-イソチオシアネートフェニル)-2-メトキシアリニンはどのように合成されますか?
N-(4-イソチオシアネートフェニル)-2-メトキシアリニンは、4-イソチオシアノフェノールと2-メトキシアリニルアミンのアミニド反応を用いて合成されます。この...
金粉蕨亭2'-O-葡萄糖甙の主な用途は何ですか?
金粉蕨亭2'-O-葡萄糖甙は主に薬理研究や医薬品製造に使用され、抗炎症作用や抗がん作用などがあります。また、その構造や性質から、合成化学や化学生理学の研究にも用...
2-(2-ニトロフェニル)酢酸ヒドライドの物理化学的性質は何ですか?
2-(2-ニトロフェニル)酢酸ヒドライドのCAS番号は114953-81-0です。この化合物は白色結晶性粉末で、分子量は244.12です。水溶性は限られており、...
5-(ヒドロキシメチル)-2-チオキソ-2,3-ジヒドロピリミジン-4(1H)-オンを取り扱う際の実験室安全事項は何ですか?
この化合物は高活性のため、取り扱いには注意が必要です。PPE(個人保護具)としてゴーグル、ガントリー、および防滴シールドを着用することが推奨されます。ドラフトチ...
11-脱氢血栓烷 b2の市場動向や研究トレンドはどうですか?
11-脱氢血栓烷 b2は、血栓溶解・抗凝固作用に関する研究で注目を集めています。特に心血管疾患の治療法開発において、市場の需要が高まっています。研究トレンドとし...
3,3-二甲基哌啶-4-酮はどのように保存すればよいですか?
3,3-二甲基哌啶-4-酮は避光、常温、乾燥した場所で保存してください。容器は密閉し、遠くから火源を離して保管することを確認してください。
掲載誌
Physical Chemistry Chemical Physics

Physical Chemistry Chemical Physics (PCCP) is an international journal co-owned by 19 physical chemistry and physics societies from around the world. This journal publishes original, cutting-edge research in physical chemistry, chemical physics and biophysical chemistry. To be suitable for publication in PCCP, articles must include significant innovation and/or insight into physical chemistry; this is the most important criterion that reviewers and Editors will judge against when evaluating submissions. The journal has a broad scope and welcomes contributions spanning experiment, theory, computation and data science. Topical coverage includes spectroscopy, dynamics, kinetics, statistical mechanics, thermodynamics, electrochemistry, catalysis, surface science, quantum mechanics, quantum computing and machine learning. Interdisciplinary research areas such as polymers and soft matter, materials, nanoscience, energy, surfaces/interfaces, and biophysical chemistry are welcomed if they demonstrate significant innovation and/or insight into physical chemistry. Joined experimental/theoretical studies are particularly appreciated when complementary and based on up-to-date approaches.














