Cell-inspired biointerfaces constructed from patterned smart hydrogels for immunoassays in whole blood

文献情報

出版日 2017-02-27

DOI 10.1039/C6TB03385G

インパクトファクター 6.331

著者

Jianwen Hou, Runhai Chen, Zhirong Xin, Hengchong Shi, Shing-Chung Wong, Jinghua Yin, Qiang Shi

原文を見る

要旨

Immunoassays have shown great advances in the fields of biomedical diagnosis. However, successful immunoassays in blood plasma or whole blood based on the designed biointerfaces are still rare. Here, a newly cell-inspired biointerface for immunoassays in blood is demonstrated. Inspired by the high resistance to protein and cell adhesion and extraordinary biological recognition of stem cells, the biointerfaces are constructed by patterning smart hydrogels (PNIPAAm-co-PNaAc) on hydrophilic layers (PEG), followed by immobilization of antibodies on the patterned hydrogels. The hierarchical biointerfaces are hydrophilic to resist blood plasma and blood cell adhesion, but exhibit high affinity to the target antigens. As a result, successful immunoassays in blood are achieved. In addition, the detection signal is further enhanced by the manipulation of the phase transition of the smart hydrogels with temperature, and the sensitivity is higher than that of the widely-used poly(acrylic acid)/(polyacrylate) platform. The biointerface is versatile and effective in antibody–antigen recognition, which offers a potential new approach for developing highly sensitive immunoassays in blood.

掲載誌

Journal of Materials Chemistry B

CiteScore: 12

自己引用率: 4.9%

年間論文数: 831

Journal of Materials Chemistry A, B & C cover high quality studies across all fields of materials chemistry. The journals focus on those theoretical or experimental studies that report new understanding, applications, properties and synthesis of materials. The journals have a strong history of publishing quality reports of interest to interdisciplinary communities and providing an efficient and rigorous service through peer review and publication. The journals are led by an international team of Editors-in-Chief and Associate Editors who are all active researchers in their fields. Journal of Materials Chemistry A, B & C are separated by the intended application of the material studied. Broadly, applications in energy and sustainability are of interest to Journal of Materials Chemistry A, applications in biology and medicine are of interest to Journal of Materials Chemistry B, and applications in optical, magnetic and electronic devices are of interest to Journal of Materials Chemistry C. More than one Journal of Materials Chemistry journal may be suitable for certain fields and researchers are encouraged to submit their paper to the journal that they feel best fits for their particular article. Example topic areas within the scope of Journal of Materials Chemistry B are listed below. This list is neither exhaustive nor exclusive. Antifouling coatings Biocompatible materials Bioelectronics Bioimaging Biomimetics Biomineralisation Bionics Biosensors Diagnostics Drug delivery Gene delivery Immunobiology Nanomedicine Regenerative medicine & Tissue engineering Scaffolds Soft robotics Stem cells Therapeutic devices image block All articles published in Journal of Materials Chemistry B from 2019 onwards will be indexed in MEDLINE®. Articles that primarily focus on providing insight into the underlying science and performance of biomaterials within a biological environment are more suited to our companion journal, Biomaterials Science.

Cell-inspired biointerfaces constructed from patterned smart hydrogels for immunoassays in whole blood

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