A general route to fluorinated 3,3-disubstituted 2-oxindoles via a photoinduced radical cyclization of N-arylacrylamides under catalyst-free conditions

文献情報

出版日 2016-03-03

DOI 10.1039/C6QO00055J

インパクトファクター 5.281

著者

Yuanyuan An, Yuewen Li

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要旨

A catalyst-free radical cyclization of N-arylacrylamides with fluorinated alkyl iodides or the Togni reagent enabled by photoenergy is presented for the first time. Under ultraviolet irradiation, the generation of fluorinated 3,3-disubstituted 2-oxindoles proceeds smoothly without any metals or photoredox catalysts. The broad reaction scope is demonstrated with good functional group tolerance. During the process, fluorinated alkyl groups can be easily incorporated.

掲載誌

Organic Chemistry Frontiers

CiteScore: 7.8

自己引用率: 8.7%

年間論文数: 724

Organic Chemistry Frontiers publishes high-quality research from across organic chemistry. Emphases are placed on studies that make significant contributions to the field of organic chemistry by reporting either new or significantly improved protocols or methodologies. Topics include, but are not limited to the following: Organic synthesis Development of synthetic methodologies Catalysis Natural products Functional organic materials Supramolecular and macromolecular chemistry Physical and computational organic chemistry

A general route to fluorinated 3,3-disubstituted 2-oxindoles via a photoinduced radical cyclization of N-arylacrylamides under catalyst-free conditions

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