Poly(d,l-lactic acid)-block-poly(N-(2-hydroxypropyl)methacrylamide) nanoparticles for overcoming accelerated blood clearance and achieving efficient anti-tumor therapy
文献情報
Nan Du, Wenxuan Guo, Qingsong Yu, Shuli Guan, Linyi Guo, Tong Shen, Hao Tang, Zhihua Gan
Well-defined poly(D,L-lactic acid)-block-poly(N-(2-hydroxypropyl)methacrylamide) (PDLLA-b-PHPMA) copolymers were synthesized by the combination of ring opening polymerization (ROP) and reversible addition–fragmentation chain transfer (RAFT) polymerization techniques. Paclitaxel loaded nanoparticles based on these copolymers were prepared with the emulsion/solvent evaporation method. The biological properties such as the interaction with macrophage cells, the cytotoxicity against 4T1 tumor cells, blood clearance, in vivo biodistribution and the anti-tumor efficacy of nanoparticles with different compositions have been investigated. Low reticuloendothelial system (RES) uptake and high tumor accumulation could be observed for PDLLA-b-PHPMA nanoparticles in the preliminary results. When compared with PEG, PHPMA showed a similar performance in decreasing macrophage uptake and prolonging blood circulation. The tumor growth inhibition assay has proved the great potential of PDLLA-b-PHPMA to act as efficient drug carriers against murine breast cancer models. More importantly, the introduction of PHPMA may help to alleviate the accelerated blood clearance (ABC) phenomenon of PDLLA-b-PEG.
関連文献
Insertion of organoindium carbenoids into rhodium halide bonds: revisiting a classic type of transition metal–group 13 metal bond formation
Tobias Steinke, Christian Gemel, Mirza Cokoja, Manuela Winter, Roland A. Fischer
DOI: 10.1039/B301928D
Identification of distinct Brønsted acidic sites in zeolite mordenite by proton localization and [27Al]-1H REAPDOR NMR
Subramanian Ganapathy, Rajiv Kumar, Laurent Delevoye, Jean-Paul Amoureux
DOI: 10.1039/B304548J
Thermolysis of fluorinated cycloalkylidene fulgides yields a new class of photochromic compounds
Mason A. Wolak, Nathan B. Gillespie, Robert R. Birge, Watson J. Lees
DOI: 10.1039/B300010A
Solvent-dependent 44 square grid and 64.82 NbO frameworks formed by Cu(Pyac)2 (bis[3-(4-pyridyl)pentane-2,4-dionato]copper(ii))
Banglin Chen, Frank R. Fronczek, Andrew W. Maverick
DOI: 10.1039/B305457H
A new type of three-dimensional framework constructed from dodecanuclear cadmium(ii) macrocycles‡
Ruihu Wang, Maochun Hong, Junhua Luo, Rong Cao, Jiabao Weng
DOI: 10.1039/B212425D
A novel approach to carbon hollow spheres and vessels from CCl4 at low temperatures
Zhengquan Li, Changzheng Wu, Rong Zhang
DOI: 10.1039/B211996J
Decomposition of Pt-intercalated hydrotalcite-like nanocomposites to produce micro/mesoporous catalysts
Masato Machida, Shin Hamada
DOI: 10.1039/B304352E
Palladacyclic catalysts in C–C and C–heteroatom bond-forming reactions
DOI: 10.1039/B211298C
Characterization of sulfur exchange reaction between polysulfides and elemental sulfur using a 35S radioisotope tracer method
Shigeru Yamada, Danhong Wang, Songri Li, Megumi Nishikawa, Eika Weihua Qian, Atsushi Ishihara, Toshiaki Kabe
DOI: 10.1039/B212438F
First generation of pentazole (HN5, pentazolic acid), the final azole, and a zinc pentazolate salt in solution: A new N-dearylation of 1-(p-methoxyphenyl) pyrazoles, a 2-(p-methoxyphenyl) tetrazole and application of the methodology to 1-(p-methoxyphenyl) pentazole
R. N. Butler, John C. Stephens, Luke A. Burke
DOI: 10.1039/B301491F
こちらもおすすめ
H-Leu-Ser-Lys-Leu-OH trifluoroacetate saltに適用される法規ガイドラインは何ですか?
CAS番号162559-45-7のH-Leu-Ser-Lys-Leu-OH trifluoroacetate saltは、GHS( Chemicals Clas...
Trimethyltin Chlorideの物理化学的性質は何ですか?
CAS番号1066-45-1のトリメチルチリドは、白色結晶性粉末で、分子量は297.77です。この化合物は水にわずかに溶けますが、酢酸、エタノール、ジエチルエー...
ニコール酸化物水和物の主な用途は何ですか?
ニコール酸化物水和物は、主に金属分離、研磨剤、酸化剤、染料製造の原料として利用されます。また、電気化学製品、触媒、分析化学の分野でも広く使用されています。
(2,3-二甲基-2H-吲唑-6-基)boronic acidを取り扱う際の実験室安全事項は何ですか?
(2,3-二甲基-2H-吲唑-6-基)boronic acidを取り扱う際は、PPE(防護服、ゴーグル、マスク、手袋)を使用する必要があります。ドラフトチャンバ...
4-ブロモ-1-メトキシ-2-(2-メトキシエトオキシ)ベンゼンは安全ですか?
4-ブロモ-1-メトキシ-2-(2-メトキシエトオキシ)ベンゼンは一般的に安全とは言えません。取扱いには注意が必要で、直接的な皮膚接触や吸入は避けてください。
4,4-双(5-甲基-2-苯并噁唑基)二苯乙烯はどの業界で使用されていますか?
4,4-双(5-甲基-2-苯并噁唑基)二苯乙烯は医薬業界、ポリマー業界、センサー業界、半導体業界で使用されています。特に、光触媒や蛍光材料として利用されています...
2,3,5,6-四氯-4-ピリジンスチオールを取り扱う際の実験室安全事項は何ですか?
2,3,5,6-四氯-4-ピリジンスチオールは非常に毒性があり、皮膚や粘膜に刺激を与える可能性があります。取り扱う際には、ゴーグル、ゴム手袋、防塵マスクを着用し...
TG 4-155はどのように合成されますか?
TG 4-155は、2-(2-メチル-1H-インドン-1-イル)エチルアミドと3,4,5-トリメトキシフェノールを反応させ、選択性的に合成できます。一般的には、...
エチルヒドロキシキニリン-6-カルボキシ酸は適用される法規ガイドラインは何ですか?
エチルヒドロキシキニリン-6-カルボキシ酸のCAS番号1261631-01-9は、GHS分類の第2クラスの腐食物質(皮膚に強い腐食性)に分類されます。また、EU...
掲載誌
Polymer Chemistry

Polymer Chemistry welcomes submissions in all areas of polymer science that have a strong focus on macromolecular chemistry. Manuscripts may cover a broad range of fields, yet no direct application focus is required.










![2-[2-(2-Methoxyethoxy)ethoxy]-2-methylpropane structure 2-[2-(2-Methoxyethoxy)ethoxy]-2-methylpropane structure](https://static.chemtradehub.com/structs/527/52788-79-1-71c1.webp)



