A library of heptyl mannose-functionalized copolymers with distinct compositions, microstructures and neighboring non-sugar motifs as potent antiadhesives of type 1 piliated E. coli

文献情報

出版日 2016-03-16

DOI 10.1039/C6PY00118A

インパクトファクター 5.582

著者

Sébastien G. Gouin, Julie Bouckaert

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要旨

A large library of mannosylated copolymers having tunable compositions, microstructures and pendant motifs neighboring mannose of distinct nature were synthesized by combining (i) sequential, batch or semi-batch RAFT (co)polymerizations of glycidyl methacrylate (GMA) and N-[7-(α-D-mannopyranosyloxy)heptyl] methacrylamide (HMM) and (ii) epoxy-amine post-modifications with ethanolamine, (2-aminoethyl)trimethylammonium chloride or taurine. Examination of the anti-adhesive properties against type 1 piliated E. coli allowed for identifying copolymers among the three series of post-modified glycopolymers capable of efficiently inhibiting bacterial adhesion at 0.1 and 1 μM (on a mannose unit basis) in pre and post-incubation adhesion assays respectively.

掲載誌

Polymer Chemistry

CiteScore: 8.6

自己引用率: 7.3%

年間論文数: 457

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A library of heptyl mannose-functionalized copolymers with distinct compositions, microstructures and neighboring non-sugar motifs as potent antiadhesives of type 1 piliated E. coli

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