Regiospecific synthesis of distally chlorinated ketones via C–C bond cleavage of cycloalkanols

文献情報

出版日 2015-12-10

DOI 10.1039/C5QO00368G

インパクトファクター 5.281

著者

Xuefeng Fan, Huijun Zhao, Jiajia Yu, Xiaoguang Bao

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要旨

A variety of distally Csp3-chlorinated ketones are synthesized with good regioselectivities via silver-catalyzed ring opening of cycloalkanols under mild reaction conditions. The reaction uses only routine, inexpensive reagents and can be scaled up to gram quantities. A novel radical-mediated C–C bond cleavage/C–Cl bond formation is proposed.

掲載誌

Organic Chemistry Frontiers

CiteScore: 7.8

自己引用率: 8.7%

年間論文数: 724

Organic Chemistry Frontiers publishes high-quality research from across organic chemistry. Emphases are placed on studies that make significant contributions to the field of organic chemistry by reporting either new or significantly improved protocols or methodologies. Topics include, but are not limited to the following: Organic synthesis Development of synthetic methodologies Catalysis Natural products Functional organic materials Supramolecular and macromolecular chemistry Physical and computational organic chemistry

Regiospecific synthesis of distally chlorinated ketones via C–C bond cleavage of cycloalkanols

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