Copper-mediated radical alkylarylation of unactivated alkenes with acetonitrile leading to fluorenes and pyrroloindoles

文献情報

出版日 2015-12-17

DOI 10.1039/C5QO00329F

インパクトファクター 5.281

著者

Xue-Qiang Chu, Zhen-Hua Xing, Hua Meng, Xiao-Ping Xu, Shun-Jun Ji

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要旨

A Cu-mediated/catalyzed selective oxidative dual C–H bond cleavage of an arene and alkylnitrile or acetone is reported. This method provides a novel approach to highly functionalized fluorene and pyrroloindole derivatives, which are useful in pharmaceutical and photoelectronic areas. In this reaction, two new C(sp3)–C(sp3) and C(Ar)–C(sp3) bonds, a quaternary center and a five-membered ring are simultaneously formed.

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Organic Chemistry Frontiers

CiteScore: 7.8

自己引用率: 8.7%

年間論文数: 724

Organic Chemistry Frontiers publishes high-quality research from across organic chemistry. Emphases are placed on studies that make significant contributions to the field of organic chemistry by reporting either new or significantly improved protocols or methodologies. Topics include, but are not limited to the following: Organic synthesis Development of synthetic methodologies Catalysis Natural products Functional organic materials Supramolecular and macromolecular chemistry Physical and computational organic chemistry

Copper-mediated radical alkylarylation of unactivated alkenes with acetonitrile leading to fluorenes and pyrroloindoles

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