Access to bicyclic hydroxamate macrocycles via intramolecular aza-(4 + 3) cyloaddition reactions of aza-oxyallylic cation intermediates

文献情報

出版日 2015-12-28

DOI 10.1039/C5QO00315F

インパクトファクター 5.281

著者

A. Acharya, J. A. Eickhoff, K. Chen, V. J. Catalano, C. S. Jeffrey

原文を見る

要旨

The intramolecular aza-(4 + 3) cycloaddition reactions of in situ generated aza-oxyallylic cations and furans have been reported for the construction of medium sized hydroxamate macrocycles. This method provides direct access to 12–18 membered bicyclic macrocycles. The highly functionalized macrocycles have been transformed easily in to a wide range of highly functionalized heterocyclic scaffolds including lactones and lactams that could serve the synthesis of complex macrocyclic natural products and pharmaceuticals.

掲載誌

Organic Chemistry Frontiers

CiteScore: 7.8

自己引用率: 8.7%

年間論文数: 724

Organic Chemistry Frontiers publishes high-quality research from across organic chemistry. Emphases are placed on studies that make significant contributions to the field of organic chemistry by reporting either new or significantly improved protocols or methodologies. Topics include, but are not limited to the following: Organic synthesis Development of synthetic methodologies Catalysis Natural products Functional organic materials Supramolecular and macromolecular chemistry Physical and computational organic chemistry

Access to bicyclic hydroxamate macrocycles via intramolecular aza-(4 + 3) cyloaddition reactions of aza-oxyallylic cation intermediates

文献情報

おすすめジャーナル

関連文献

Synthesis of multi-functionalized hydrogels by a thiolactone-based synthetic protocol

High performance polymer solar cells based on a two dimensional conjugated polymer from alkylthienyl-substituted benzodifuran and benzothiadiazole

Studying the polymerization initiation efficiency of acetophenone-type initiators via PLP-ESI-MS and femtosecond spectroscopy

From glycidyl carbonate to hydroxyurethane side-groups in alternating fluorinated copolymers

Highly pH-sensitive polyurethane exhibiting shape memory and drug release

A supramolecular approach for fabrication of photo-responsive block-controllable supramolecular polymers

Additions and Corrections

Effect of polymer chemistry on globular protein–polymer block copolymer self-assembly

White light emission of multi-chromophore photoluminescent nanoparticles using polyacrylate scaffold copolymers with pendent polyfluorene groups

Injectable enzymatically crosslinked hydrogels based on a poly(l-glutamic acid) graft copolymer

こちらもおすすめ

1-{3-[5-(エチルカルボンイル)-2,4-ジメチル-1H-ピロロール-3-基]プロパニル}ピペリジン-4-カルボン酸について、適用される法規ガイドラインは何ですか？

2,2-二氟-1,3-ベンゾジオキサン-5-カルボキシlic酸とは何ですか？

8-氯-4-色原酮の代替品はありますか？

エチル6,6-ジメチル-4,5,6,7-テトラヒドロ-1H-インドアゼー-3-カルボキシレートとは何ですか？

4-叔丁基-6-氯-嘧啶に適用される法規ガイドラインは何ですか？

維库溴铵杂质Bはどのように合成されますか？

2-(4-氟苄基)-吡咯烷の物理化学的性質は何ですか？

3-喹啉甲醛（2-チロール-8-エチル）は安全ですか？

エチル3-(ヒドロキシメチル)-1H-ピロール-2-カルボキシレートはどのように保存すればよいですか？

哌拉西林杂质Dは安全ですか？

掲載誌

Organic Chemistry Frontiers

おすすめ化合物

Dipotassium 7-hydroxy-1,3-naphthalenedisulfonate

Butylphenyl Methylpropional

Tris(2-ethylhexyl) 4,4',4''-(1,3,5-triazine-2,4,6-triyltriimino)tribenzoate

Methyl 4-chloro-2-pyridinecarboxylate

Pimecrolimus

おすすめサプライヤー