Cu-Mediated 2,2,2-trifluoroethylation of terminal alkynes using 1,1-dichloro-2,2,2-trifluoroethane (HCFC-123)

文献情報

出版日 2015-08-14

DOI 10.1039/C5QO00210A

インパクトファクター 5.281

著者

En-Jian Han, Yan Sun, Qian Shen, Qing-Yun Chen, Yong Guo, Yan-Gen Huang

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要旨

The title reaction provides a novel utilization of ozone-depleting/global-warming HCFCs as a new carbon–carbon cross-coupling model of various terminal alkynes by activating two inert C–Cl bonds successively. This protocol provided trifluoroethylated alkynes efficiently under mild reaction conditions and was compatible with a broad range of functional groups. An example of the synthesis of a terbinafine analogue is shown. Some mechanistic experiments including deuterated reagents and radical/SET inhibitors are described.

掲載誌

Organic Chemistry Frontiers

CiteScore: 7.8

自己引用率: 8.7%

年間論文数: 724

Organic Chemistry Frontiers publishes high-quality research from across organic chemistry. Emphases are placed on studies that make significant contributions to the field of organic chemistry by reporting either new or significantly improved protocols or methodologies. Topics include, but are not limited to the following: Organic synthesis Development of synthetic methodologies Catalysis Natural products Functional organic materials Supramolecular and macromolecular chemistry Physical and computational organic chemistry

Cu-Mediated 2,2,2-trifluoroethylation of terminal alkynes using 1,1-dichloro-2,2,2-trifluoroethane (HCFC-123)

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