Synthesis of Passerini adducts from aldehydes and isocyanides under the auxiliary of water

文献情報

出版日 2015-07-23

DOI 10.1039/C5QO00202H

インパクトファクター 5.281

著者

Ming Li, Bin Qiu, Xiang-Jing Kong, Li-Rong Wen

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要旨

An efficient protocol for the synthesis of the Passerini adducts α-acyloxycarboxamides from aldehydes, isocyanides and water in a molecular ratio of 3 : 1 : 3 was described. The possible mechanism for the reaction was discussed by employing cross condensation and H218O isotope labeling experiments. This method offers a straightforward access to α-acyloxycarboxamides bearing two identical functional groups in high yields under mild conditions.

掲載誌

Organic Chemistry Frontiers

CiteScore: 7.8

自己引用率: 8.7%

年間論文数: 724

Organic Chemistry Frontiers publishes high-quality research from across organic chemistry. Emphases are placed on studies that make significant contributions to the field of organic chemistry by reporting either new or significantly improved protocols or methodologies. Topics include, but are not limited to the following: Organic synthesis Development of synthetic methodologies Catalysis Natural products Functional organic materials Supramolecular and macromolecular chemistry Physical and computational organic chemistry

Synthesis of Passerini adducts from aldehydes and isocyanides under the auxiliary of water

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