Synthesis of α-enamino esters via Cu(ii)-promoted dehydrogenation of α-amino acid esters: application to the synthesis of polysubstituted pyrroles

文献情報

出版日 2015-09-29

DOI 10.1039/C5QO00182J

インパクトファクター 5.281

著者

Nini Zhou, Zhongle Li, Zhixiang Xie

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要旨

α-Enamino esters were efficiently prepared directly from readily available α-amino acid esters using a Cu(II)-promoted dehydrogenation with broad functional group tolerance and good to excellent yields. Moreover, the first application of α-enamino esters for the synthesis of polysubstituted pyrroles was achieved using an oxidative coupling with alkynes under Cu(II)-promoted conditions via intermolecular carbometalation of the alkyne in high yields.

掲載誌

Organic Chemistry Frontiers

CiteScore: 7.8

自己引用率: 8.7%

年間論文数: 724

Organic Chemistry Frontiers publishes high-quality research from across organic chemistry. Emphases are placed on studies that make significant contributions to the field of organic chemistry by reporting either new or significantly improved protocols or methodologies. Topics include, but are not limited to the following: Organic synthesis Development of synthetic methodologies Catalysis Natural products Functional organic materials Supramolecular and macromolecular chemistry Physical and computational organic chemistry

Synthesis of α-enamino esters via Cu(ii)-promoted dehydrogenation of α-amino acid esters: application to the synthesis of polysubstituted pyrroles

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