A fast track strategy toward highly functionalized dendrimers with different structural layers: an “onion peel approach”

文献情報

出版日 2015-01-16

DOI 10.1039/C4PY01761G

インパクトファクター 5.582

著者

Rishi Sharma, Issan Zhang, Leïla Abbassi, Rabindra Rej, Dusica Maysinger, René Roy

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要旨

An accelerated strategy depending on different chemical building blocks between each layer, coined “onion peel”, was used to construct a library of third generation dendrimers with 108, 180 and 252 hydroxyl surface groups using a combination of microwave assisted highly efficient CuAAC and thiol–ene reactions. These dendrimers were conveniently acquired with high purity and good yields in a divergent manner using a variety of orthogonal and dense AB3, AB5, and AB7 building blocks. The resulting polyhydroxylated dendrimers tested in several human cell types did not impair mitochondrial metabolic function or cell viability suggesting that they are good candidates for applications in biological investigations.

掲載誌

Polymer Chemistry

CiteScore: 8.6

自己引用率: 7.3%

年間論文数: 457

Polymer Chemistry welcomes submissions in all areas of polymer science that have a strong focus on macromolecular chemistry. Manuscripts may cover a broad range of fields, yet no direct application focus is required.

A fast track strategy toward highly functionalized dendrimers with different structural layers: an “onion peel approach”

文献情報

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Polymer Chemistry

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