A tandem mass spectrometry-based method to assess the architectural purity of synthetic polymers: a case of a cyclic polylactide obtained by click chemistry

文献情報

出版日 2014-08-29

DOI 10.1039/C4PY01087F

インパクトファクター 5.582

著者

Philippe Dubois, Olivier Coulembier, Pascal Gerbaux, Antony Memboeuf

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要旨

A tandem mass spectrometry-based method is developed to determine the degree of purity achieved in the cyclization of a linear poly(L-lactide) prepared by copper-catalyzed alkyne-azide cycloaddition. When proton nuclear magnetic resonance, size-exclusion chromatography, and single-stage mass spectrometry are unable to demonstrate the presence of a residual linear polymer, the proposed ESI-tandem mass spectrometry methodology allows detection of starting material traces (<5%) based on radically different collision-induced dissociation (CID) behaviours. The technique is believed to be readily adaptable to numerous isomeric pairs of macromolecules presenting different CID characteristics.

掲載誌

Polymer Chemistry

CiteScore: 8.6

自己引用率: 7.3%

年間論文数: 457

Polymer Chemistry welcomes submissions in all areas of polymer science that have a strong focus on macromolecular chemistry. Manuscripts may cover a broad range of fields, yet no direct application focus is required.

A tandem mass spectrometry-based method to assess the architectural purity of synthetic polymers: a case of a cyclic polylactide obtained by click chemistry

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