Development of a tripartite solvent blend for sustainable chromatography
文献情報
Florence M. Chardon, Nicole Blaquiere, Georgette M. Castanedo, Stefan G. Koenig
A three-component solvent system (isopropyl acetate, methanol, and heptane) was designed to empower routine chromatographic separation of a wide range of compounds, from polar to nonpolar molecules, without the need for undesired chlorinated solvent. This system was evaluated with a pharmaceutically-relevant set of compounds via practical silica gel chromatographic purification, making the solvent blend an attractive sustainable chromatography solution for drug discovery efforts.
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