Mild and metal-free oxy- and amino-fluorination for the synthesis of fluorinated heterocycles
文献情報
Dixit Parmar, Magnus Rueping
A mild intramolecular fluoro-cyclisation reaction of benzylic alcohols and amines has been developed. This strategy uses commercially available Selectfluor to trigger electrophilic cyclisations to afford fluorinated heterocycles containing 1,3-disubstitution. The dual role of the reagent as a fluorine source and a base is shown to be crucial for reactivity.
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