A general and practical oxidation of alcohols to primary amides under metal-free conditions‡
文献情報
Jian-Bo Feng, Helfried Neumann, Anahit Pews-Davtyan, Matthias Beller
A general procedure for oxidation of both benzyl alcohols and alkyl alcohols to primary amides under catalyst free conditions has been developed. 34 examples of primary amides were produced from their corresponding alcohols in moderate to excellent yields. This is a practical procedure for primary amides synthesis; water and tert-butanol are the only by-products. A commercial drug, Piracetam, was prepared in one step with 73% yield as well.
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