Cancer antigen 125 detection using the plasmon resonance scattering properties of gold nanorods

文献情報

出版日 2013-01-21

DOI 10.1039/C3AN36614F

インパクトファクター 4.616

著者

Kaixia Zhang, Xiaolei Shen

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要旨

Cancer antigen 125 (CA 125) is a useful tumor marker with a threshold value of 35 U mL−1 expressed by more than 80% of patients with non-mucinous epithelial ovarian cancer. In this work, a novel strategy for the analysis of CA 125 using the plasmon resonance scattering (PRS) properties of gold nanorods was proposed. The gold nanorod (GNR)–anti-CA 125 conjugates were prepared first. The immunoreaction between the GNR modified CA 125 antibody and CA 125 took place in aqueous solution after the addition of CA 125. The target protein concentration was determined by analyzing the level of GNR aggregation caused by CA 125 antibody–antigen interactions using PRS. At a concentration of 1.0–80 U mL−1, CA 125 could be determined with a detection limit of 0.4 U mL−1. The PRS immunosensor showed high sensitivity, selectivity, and reproducibility. Determination of CA 125 in serum samples showed good recovery.

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CiteScore: 7.8

自己引用率: 5.6%

年間論文数: 653

Analyst publishes analytical and bioanalytical research that reports premier fundamental discoveries and inventions, and the applications of those discoveries, unconfined by traditional discipline barriers.

Cancer antigen 125 detection using the plasmon resonance scattering properties of gold nanorods

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