Simple enrichment and analysis of plasma lysophosphatidic acids

文献情報

出版日 2013-09-26

DOI 10.1039/C3AN01168B

インパクトファクター 4.616

著者

Jialu Wang, Martha Sibrian-Vazquez, Jorge O. Escobedo, Mark Lowry, Lei Wang, Yu-Hsuan Chu, Richard G. Moore, Robert M. Strongin

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要旨

A simple and highly efficient technique for the analysis of lysophosphatidic acid (LPA) subspecies in human plasma is described. The streamlined sample preparation protocol furnishes the five major LPA subspecies with excellent recoveries. Extensive analysis of the enriched sample reveals only trace levels of other phospholipids. This level of purity not only improves MS analyses, but enables HPLC post-column detection in the visible region with a commercially available fluorescent phospholipids probe. Human plasma samples from different donors were analyzed using the above method and validated by LC-ESI/MS/MS.

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CiteScore: 7.8

自己引用率: 5.6%

年間論文数: 653

Analyst publishes analytical and bioanalytical research that reports premier fundamental discoveries and inventions, and the applications of those discoveries, unconfined by traditional discipline barriers.

Simple enrichment and analysis of plasma lysophosphatidic acids

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