Investigation of glycopolymer–lectin interactions using QCM-d: comparison of surface binding with inhibitory activity

文献情報

出版日 2012-04-27

DOI 10.1039/C2PY20140B

インパクトファクター 5.582

著者

Yanzi Gou, Sarah-Jane Richards, David M. Haddleton, Matthew I. Gibson

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要旨

Glycopolymers offer many opportunities for interfacing synthetic materials with biological systems. However, the nature of the interactions between glycopolymers and their biological targets, lectins, and the structural features necessary to obtain high-affinity materials are not fully understood. Here, the enhancement in binding affinity of multivalent glycopolymers to their corresponding lectins is investigated by quartz-crystal microbalance with dissipation monitoring (QCM-d). This technique allows the conformation of the adsorbed polymers to be probed and the direct observation of spanning of multiple binding sites on lectin-functional surfaces. The measured affinity was compared to the anti-adhesion activity of the polymers in solution, and it is shown that increased association constants did not directly correlate with inhibitory activity.

掲載誌

Polymer Chemistry

CiteScore: 8.6

自己引用率: 7.3%

年間論文数: 457

Polymer Chemistry welcomes submissions in all areas of polymer science that have a strong focus on macromolecular chemistry. Manuscripts may cover a broad range of fields, yet no direct application focus is required.

Investigation of glycopolymer–lectin interactions using QCM-d: comparison of surface binding with inhibitory activity

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