Pepsin-inspired polyurethanes containing a tyrosine–fumaric acid–tyrosine segment

文献情報

出版日 2011-12-15

DOI 10.1039/C2PY00481J

インパクトファクター 5.582

著者

Haoxiang Lu, Wei Wang, Zhen Zheng, Peiyu Sun, Xinling Wang, Feng-Chih Chang

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要旨

Two kinds of novel peptide mimetic pepsin-inspired degradable polyurethanes were synthesized and characterized. A synthetic pseudo tripeptide acted as chain extender and provided active sites for pepsin biodegradation. In vitrodegradation behavior was investigated in simulated gastric fluid containing pepsin, and assessed by 1H NMR, mass loss and SEM. The results indicated that the pseudo peptide bonds in polyurethanes were effectively digested by the action of pepsin. Furthermore, the rate and degree of pepsin-inspired polyurethanes in simulated gastric fluid containing pepsin could be controlled by alteration of the soft segments and activity of pepsin. The influence of the polymers on human umbilical vein endothelial cells was evaluated by WST-1 assay. The results indicated that the polymers sustained much higher cell viability than the controls.

掲載誌

Polymer Chemistry

CiteScore: 8.6

自己引用率: 7.3%

年間論文数: 457

Polymer Chemistry welcomes submissions in all areas of polymer science that have a strong focus on macromolecular chemistry. Manuscripts may cover a broad range of fields, yet no direct application focus is required.

Pepsin-inspired polyurethanes containing a tyrosine–fumaric acid–tyrosine segment

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