Acyl hydrazides as peptoid sub-monomers

文献情報

出版日 2011-09-05

DOI 10.1039/C1CC12750K

インパクトファクター 6.222

著者

Bani Kanta Sarma, Muhammed Yousufuddin, Thomas Kodadek

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要旨

The use of acyl hydrazides as peptoid sub-monomers is investigated. We demonstrate here that azapeptoids derived entirely from acyl hydrazides can be made conveniently and efficiently using standard peptoid sub-monomer chemistry. Structural studies reveal that the main chain amide bond in these molecules predominantly adopts a trans conformation. A high-quality one bead one compound library of tetramers was made by split and pool synthesis and we found that the identity of the molecule on a single bead could be determined by tandem MALDI mass spectrometry.

掲載誌

Chemical Communications

CiteScore: 8.6

自己引用率: 4.7%

年間論文数: 2458

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