Self-immolative linkers in polymeric delivery systems

文献情報

出版日 2010-11-18

DOI 10.1039/C0PY00324G

インパクトファクター 5.582

著者

Christopher A. Blencowe, Andrew T. Russell, Francesca Greco, Wayne Hayes, David W. Thornthwaite

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要旨

There has been significant interest in the methodologies of controlled release for a diverse range of applications spanning drug delivery, biological and chemical sensors, and diagnostics. The advancement in novel substrate-polymer coupling moieties has led to the discovery of self-immolative linkers. This new class of linker has gained popularity in recent years in polymeric release technology as a result of stable bond formation between protecting and leaving groups, which becomes labile upon activation, leading to the rapid disassembly of the parent polymer. This ability has prompted numerous studies into the design and development of self-immolative linkers and the kinetics surrounding their disassembly. This review details the main concepts that underpin self-immolative linker technologies that feature in polymeric or dendritic conjugate systems and outlines the chemistries of amplified self-immolative elimination.

掲載誌

Polymer Chemistry

CiteScore: 8.6

自己引用率: 7.3%

年間論文数: 457

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Self-immolative linkers in polymeric delivery systems

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