Design and development of quantum dots and other nanoparticles based cellular imaging probe

文献情報

出版日 2010-11-10

DOI 10.1039/C0CP00726A

インパクトファクター 3.676

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要旨

One goal of nanotechnology is to prepare cellular nanoprobes for various biological applications where conventional molecular probes fall short of long-term stability and simultaneous detection of multiple signals. Successful development of cellular nanoprobes requires the availability of a library of functional nanoparticles, knowledge of their interactions with cells and mechanism of cellular entry and to modulate these interactions by appropriate design of surface functionality. Although a great deal of research has been done in past 15 years, only limited success has been achieved in live cell labeling with high specificity, sub-cellular targeting and single molecule trafficking. This article focuses on the author's effort in making cellular imaging nanoprobes from different nanoparticles and discusses the most critical issues in the context of current knowledge, such as different variables that often influence labeling, non-specific binding/uptake of nanoprobes and specific live cell labeling. Finally, the important role of coating chemistry to overcome these problems has been highlighted and some successful labeling results have been summarized.

掲載誌

Physical Chemistry Chemical Physics

CiteScore: 5.5

自己引用率: 10.3%

年間論文数: 3036

Physical Chemistry Chemical Physics (PCCP) is an international journal co-owned by 19 physical chemistry and physics societies from around the world. This journal publishes original, cutting-edge research in physical chemistry, chemical physics and biophysical chemistry. To be suitable for publication in PCCP, articles must include significant innovation and/or insight into physical chemistry; this is the most important criterion that reviewers and Editors will judge against when evaluating submissions. The journal has a broad scope and welcomes contributions spanning experiment, theory, computation and data science. Topical coverage includes spectroscopy, dynamics, kinetics, statistical mechanics, thermodynamics, electrochemistry, catalysis, surface science, quantum mechanics, quantum computing and machine learning. Interdisciplinary research areas such as polymers and soft matter, materials, nanoscience, energy, surfaces/interfaces, and biophysical chemistry are welcomed if they demonstrate significant innovation and/or insight into physical chemistry. Joined experimental/theoretical studies are particularly appreciated when complementary and based on up-to-date approaches.