Rapid cell mapping using nanoparticles and SERRS

文献情報

出版日 2008-11-19

DOI 10.1039/B815117B

インパクトファクター 4.616

著者

Robert J. Stokes, Fiona McKenzie, Emma McFarlane, Alastair Ricketts, Laurence Tetley, Karen Faulds, James Alexander, Duncan Graham

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要旨

Bone marrow-derived immune cells (macrophages) treated with gold and silver nanoparticles before fixation and dye staining have been analysed by multiple wavelength line scanning surface enhanced resonance Raman scattering (SERRS) mapping. The method yields high selectivity and sensitivity within short analysis times, identifying nanoparticle aggregates in secondary lysosomes. Using routine cell stains, the output from fluorescence, Raman and SERRS is quantified at four wavelengths of excitation, demonstrating the potential at longer biologically compatible wavelengths of using nanoparticles with cell stains for superior cell mapping.

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Analyst

CiteScore: 7.8

自己引用率: 5.6%

年間論文数: 653

Analyst publishes analytical and bioanalytical research that reports premier fundamental discoveries and inventions, and the applications of those discoveries, unconfined by traditional discipline barriers.

Rapid cell mapping using nanoparticles and SERRS

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