Functional biomimetic models for the active site in the respiratory enzyme cytochrome c oxidase

文献情報

出版日 2008-09-04

DOI 10.1039/B808070B

インパクトファクター 6.222

著者

James P. Collman, Richard A. Decréau

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要旨

A functional analog of the active site in the respiratory enzyme, cytochrome c oxidase (CcO) reproduces every feature in CcO's active site: a myoglobin-like heme (heme a3), a distal tridentate imidazole copper complex (CuB), a phenol (Tyr244), and a proximal imidazole. When covalently attached to a liquid-crystalline SAM film on an Au electrode, this functional model continuously catalyzes the selective four-electron reduction of dioxygen at physiological potential and pH, under rate-limiting electron flux (as occurs in CcO).

掲載誌

Chemical Communications

CiteScore: 8.6

自己引用率: 4.7%

年間論文数: 2458

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