Antibody–gold quantum dot–PAMAM dendrimer complex as an immunoglobulin immunoassay

文献情報

出版日 2008-03-20

DOI 10.1039/B718730K

インパクトファクター 4.616

著者

Robert C. Triulzi, Miodrag Micic, Jhony Orbulescu, Silvia Giordani, Bill Mueller, Roger M. Leblanc

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要旨

Gold quantum dots (AuQDs) were synthesized and electrostatically conjugated to goat-derived anti-human IgG for the purpose of detecting human IgG in solution over a broad range of concentrations. The system is able to detect human IgG by linear fluorescence quenching over a micromolar to nanomolar concentration range. We have demonstrated the specificity and a wide dynamic range of the proposed immunoassay. The quenching is a result of competitive surface quenching of the AuQDs. Characterization, details of the immunoassay, and the quenching mechanism, are discussed.

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CiteScore: 7.8

自己引用率: 5.6%

年間論文数: 653

Analyst publishes analytical and bioanalytical research that reports premier fundamental discoveries and inventions, and the applications of those discoveries, unconfined by traditional discipline barriers.

Antibody–gold quantum dot–PAMAM dendrimer complex as an immunoglobulin immunoassay

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