PCB-based integration of electrochemiluminescence detection for microfluidic systems

文献情報

出版日 2007-03-26

DOI 10.1039/B701296A

インパクトファクター 4.616

著者

Patrick Pittet, Guo-Neng Lu, Jean-Marc Galvan, Rosaria Ferrigno, Loïc J. Blum, Béatrice Leca-Bouvier

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要旨

This communication presents an instrumental development based on the printed circuit board (PCB) technology to integrate electrochemiluminescence (ECL) analysis in microfluidic systems. PCB gold macro- (10 mm2) and micro- (0.09 mm2) electrodes and two ECL microfluidic devices are designed, fabricated and tested via luminol ECL detection. Potential modulation is performed between 0.7 and 0 V vs. Ag/AgCl for luminol oxidation, thus giving rise to on/off ECL responses in the presence of hydrogen peroxide. Synchronous detection is adopted to allow weak ECL signal recovery at a very low signal-to-noise ratio (SNR). The detection limit obtained with the two ECL microfluidic devices is 50 nM and 100 nM H2O2 for macroelectrodes and microelectrodes, respectively.

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CiteScore: 7.8

自己引用率: 5.6%

年間論文数: 653

Analyst publishes analytical and bioanalytical research that reports premier fundamental discoveries and inventions, and the applications of those discoveries, unconfined by traditional discipline barriers.

PCB-based integration of electrochemiluminescence detection for microfluidic systems

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