A pragmatic and readily implemented quality control strategy for HPLC-MS and GC-MS-based metabonomic analysis

文献情報

出版日 2006-08-15

DOI 10.1039/B604498K

インパクトファクター 4.616

著者

Timothy Sangster, Hilary Major, Robert Plumb, Amy J. Wilson, Ian D. Wilson

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要旨

Metabonomic/metabolomic studies can involve the analysis of large numbers of samples for the detection of biomarkers and confidence in the analytical data, generated by methods such as GC and HPLC-MS, requires active measures on the part of the analyst. However, quality control for complex multi-component samples such as biofluids, where many of the components of interest in the sample are unknown prior to analysis, poses significant problems. Here the repeat analysis of a pooled sample throughout the run, thereby enabling the analysis to be monitored and controlled using targeted inspection of the data and pattern recognition, is advocated as a pragmatic solution to this problem.

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CiteScore: 7.8

自己引用率: 5.6%

年間論文数: 653

Analyst publishes analytical and bioanalytical research that reports premier fundamental discoveries and inventions, and the applications of those discoveries, unconfined by traditional discipline barriers.

A pragmatic and readily implemented quality control strategy for HPLC-MS and GC-MS-based metabonomic analysis

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