No delayed temporal response to sample concentration changes during enhanced microdialysis sampling using cyclodextrins and antibody-immobilized microspheres

文献情報

出版日 2005-10-27

DOI 10.1039/B504180E

インパクトファクター 4.616

著者

Xiaoping Ao, Julie A. Stenken

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要旨

The temporal response to concentration changes external to a microdialysis probe containing trapping agents in the perfusion fluid was studied. Native β-cyclodextrin and a water-soluble β-cyclodextrin polymer were used as trapping agents in the microdialysis perfusion fluid to study the temporal concentration response to carbamazepine, a hydrophobic analyte. The temporal response of microdialysis probes containing antibody-immobilized microspheres against five different cytokines (tumor necrosis factor-α (TNF-α), interferon-γ (IFN-γ), interleukin-2 (IL-2), IL-4, and IL-5) to concentration changes outside of the probe was also determined. In both cases, no delayed temporal response of enhanced microdialysis was observed for either carbamazepine or the cytokines as compared to standard microdialysis sampling procedures.

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CiteScore: 7.8

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年間論文数: 653

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No delayed temporal response to sample concentration changes during enhanced microdialysis sampling using cyclodextrins and antibody-immobilized microspheres

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