A general method for making bicyclic compounds with nitrogen at a bridgehead—application to the halichlorine spiro subunit
文献情報
Derrick L. J. Clive, Maolin Yu, Zhiyong Li
N-Protected β-amino aldehydes having the nitrogen in a ring are easily converted into Morita–Baylis–Hillman adducts; O-acetylation and N-deprotection result in spontaneous cyclization to bicyclic structures having nitrogen at a bridgehead.
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