On-line atmospheric pressure matrix-assisted laser desorption/ionization mass spectrometry

文献情報

出版日 2004-06-07

DOI 10.1039/B404178J

インパクトファクター 4.616

著者

Jürg M. Daniel, Sille Ehala, Sebastian D. Friess, Renato Zenobi

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要旨

A new technique is presented for the coupling of atmospheric pressure matrix-assisted laser desorption/ionization (AP-MALDI) mass spectrometry with liquid delivery systems. Mass measurements of polymers and peptides are demonstrated using a co-dissolved matrix, e.g. α-cyano-4-hydroxycinnamic acid (HCCA). Improvements in terms of sensitivity are achieved by optimizing the shape und control of the exit capillary and by using a laser (355 nm) at a 1 kHz repetition rate. Two calibration experiments promise a good applicability of the presented coupling method for quantitative measurements. The limit of detection achieved so far is 500 nM for peptides in methanol solution containing 25 mM HCCA.

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CiteScore: 7.8

自己引用率: 5.6%

年間論文数: 653

Analyst publishes analytical and bioanalytical research that reports premier fundamental discoveries and inventions, and the applications of those discoveries, unconfined by traditional discipline barriers.

On-line atmospheric pressure matrix-assisted laser desorption/ionization mass spectrometry

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