Combined application of organozinc chemistry and one-pot hydroboration–Suzuki coupling to the synthesis of amino acids

文献情報

出版日 2003-02-20

DOI 10.1039/B300536D

インパクトファクター 3.876

著者

Arantxa Rodríguez, David D. Miller, Richard F. W. Jackson

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要旨

Hydroboration using 9-BBN-H of the protected enantiomerically pure but-3-enylglycine derivative 11, prepared by copper-catalysed allylation of the serine-derived organozinc reagent 1, followed by Suzuki coupling of the derived borane with a variety of aromatic halides, 2-bromopyridine and 2-bromopropene gives the protected amino acids 14a–l and 15. This method augments our previous methods for the synthesis of phenylalanine homologues.

掲載誌

Organic & Biomolecular Chemistry

CiteScore: 3.4

自己引用率: 10.3%

年間論文数: 1041

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