New cytotoxic cembrane based diterpenes from the soft corals Sarcophyton cherbonnieri and Nephthea sp.

文献情報

出版日 2003-02-24

DOI 10.1039/B210039H

インパクトファクター 3.876

著者

Harald Gross, Stefan Kehraus, Markus Nett, Gabriele M. König, Winfried Beil, Anthony D. Wright

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要旨

Chemical investigation of the two soft corals Nephthea sp. and Sarcophyton cherbonnieri, collected from the Fiji Islands and the Great Barrier Reef, respectively, led to the isolation of three new furano-cembranoids (1–3), two seco-cembranoid acetates (5, 6), along with the known compounds sarcoglaucol (4) and decaryiol (7). The structures of the new compounds were elucidated by employing spectroscopic techniques (NMR, MS, UV, IR and CD). Seco-cembranoids are extremely rare structures. Compounds 1, 3, and 7 were found to be cytotoxic towards several tumor cell lines (GI50 values ranged from 0.15 to 8.6 µg mL−1). Compound 7 arrests the cell cycle in the G2/M phase.

掲載誌

Organic & Biomolecular Chemistry

CiteScore: 3.4

自己引用率: 10.3%

年間論文数: 1041

Organic & Biomolecular Chemistry (OBC) publishes original and high impact research and reviews in organic chemistry. We welcome research that shows new or significantly improved protocols or methodologies in total synthesis, synthetic methodology or physical and theoretical organic chemistry as well as research that shows a significant advance in the organic chemistry or molecular design aspects of chemical biology, catalysis, supramolecular and macromolecular chemistry, theoretical chemistry, mechanism-oriented physical organic chemistry, medicinal chemistry or natural products. Articles published in the journal should report new work which makes a highly-significant impact in the field. Routine and incremental work is generally not suitable for publication in the journal. More details about key areas of our scope are below. In all cases authors should include in their article clear rationale for why their research has been carried out.