Dose-Response

Dose-Response is an open access peer-reviewed online journal publishing will publish high quality, original findings, clinical observation or report, epidemiological analysis, comprehensive or narrative review, letter to the Editor, and editorial specifically for the original work accompanied same issue, on the occurrence of dose-response relationships across a broad range of disciplines. These will include the dose-response investigation in the genomics, epigenetics, biochemistry, molecular biology, physiology and toxicology, pharmacology, medicine, experimental biology, as well as environmental and related sciences, for the responses of these biological variables to environmental chemical, factors, radiation, climate changes (heat, air pollution, geographic variation), life-style change, and even biological stress, and the underlying mechanisms by which nonlinear dose-response occurs. Particular interest focuses on experimental evidence providing mechanistic understanding of nonlinear dose-response relationships. Target Audience Researchers who explore fundamental hormetic and/or adaptive mechanisms as well as those interested in risk assessments of air pollutions, chemicals, metals, pharmaceuticals, heat (climate) changes, ionizing and non-ionizing radiation, life-style changes, and physiological and pathological (early and late) remodeling and (temporal and permanent) dysfunction. Article Types Original research or short reports, clinical observation or case report, comprehensive or narrative reviews on specific topics, commentaries, letters to the editor and also editorial specifically for the original work published in the same issue. Topics of Interest U-shaped Dose Response J-shaped Dose Response Non-monotonic Dose Response Non-linearity Hormesis/Hormetic Dose Response Biphasic Dose Response Pre/Post Conditioning Adaptive Response Drug resistance Mechanistic study on the difference for low and high dose effect Essential and non-essential metal toxic differences Interruption of the Dose-Response with two-hits