High-resolution magic-angle spinning NMR metabolic profiling with spatially localized spectroscopy under slow sample spinning
文献情報
Owing to its feasibility and versatility, High-Resolution Magic-Angle Spinning (HRMAS) NMR spectroscopy is considered an essential analytical technique in metabolomics for assessing the biochemical composition of tissue samples. Localized profiling with HRMAS has recently emerged and shown promise for spatial resolution of metabolic profiles within the sampling tissues. However, the requisite sample spinning in a few kHz can perturb the tissues spatially and morphologically. This study explored a simple approach to slow sample spinning experiments at 500 Hz without needing pulse-assist sideband suppression experiments to acquire localized spectral data. Slow-spinning localized one-and two-dimensional spectroscopy, including Total Correlation Spectroscopy (TOCSY), were explored on soft tissues for metabolic profiling. We also examined inhomogeneous radiofrequency B1 field distribution across the sampling volume, which can affect the quantification analysis.
おすすめジャーナル

New Journal of Chemistry

Crystallography Reports

Chemical Communications

Journal of Saudi Chemical Society

Nature Medicine

Journal of Natural Medicines

Chemistry Education Research and Practice

Current Opinion in Solid State & Materials Science

Russian Journal of Bioorganic Chemistry

Russian Journal of Coordination Chemistry
関連文献
Combining surface topography with polymer chemistry: exploring new interfacial biological phenomena
Dan Li, Qing Zheng, Yanwei Wang, Hong Chen
DOI: 10.1039/C3PY00739A
RAFT/MADIX (co)polymerization of vinyl trifluoroacetate: a means to many ends
Jean-Daniel Marty, Mathias Destarac
DOI: 10.1039/C3PY01109G
Polymer patchy colloids with sticky patches
Yi Zhao, Rüdiger Berger, Katharina Landfester, Daniel Crespy
DOI: 10.1039/C3PY01096A
Preparation of a D–A polymer with disilanobithiophene as a new donor component and application to high-voltage bulk heterojunction polymer solar cells
Joji Ohshita, Makoto Nakashima, Daiki Tanaka, Yasushi Morihara, Hiroyuki Fueno, Kazuyoshi Tanaka
DOI: 10.1039/C3PY01157G
Combining oxyanionic polymerization and click-chemistry: a general strategy for the synthesis of polyether polyol macromonomers
Anja Thomas, Kerstin Niederer, Frederik Wurm, Holger Frey
DOI: 10.1039/C3PY01078C
Porphyrin-containing hyperbranched supramolecular polymers: enhancing 1O2-generation efficiency by supramolecular polymerization
Yiliu Liu, Zehuan Huang, Kai Liu, Hans Kelgtermans, Wim Dehaen, Zhiqiang Wang, Xi Zhang
DOI: 10.1039/C3PY01036H
Scalable synthesis and derivation of functional polyesters bearing ene and epoxide side chains
Yunfeng Yan, Daniel J. Siegwart
DOI: 10.1039/C3PY01474F
Superheated high-temperature size-exclusion chromatography with chloroform as the mobile phase for π-conjugated polymers
Xianwen Lou, Joost L. J. van Dongen, Yasmine Braeken, Jeroen Brebels, Gijs W. P. van Pruissen, Weiwei Li, Martijn M. Wienk, René A. J. Janssen
DOI: 10.1039/C3PY00933E
The use of a carbon paste electrode mixed with multiwalled carbon nanotube/electroactive polyimide composites as an electrode for sensing ascorbic acid
Tsao-Cheng Huang, Lu-Chen Yeh, Hsiu-Ying Huang, Zheng-Yong Nian, Yi-Chun Yeh, Yi-Chen Chou, Jui-Ming Yeh, Mei-Hui Tsai
DOI: 10.1039/C3PY00787A
Photo-induced cobalt-mediated radical polymerization of vinyl acetate
Xuelang Miao, Wei Zhu, Zhengbiao Zhang, Wei Zhang, Xiulin Zhu, Jian Zhu
DOI: 10.1039/C3PY00913K
こちらもおすすめ
「邻羟基阿托伐他汀内酯标准品」に適用される法規ガイドelinesは何ですか?
CAS番号163217-74-1の「邻羟基阿托伐他汀内酯标准品」は、GHS分類では危険物に分類されず、主にREACH規則とFDA/EPAの管理対象となります。R...
メチル(3R)-3-アミノ-2,3-ジヒドロ-1-ベンゾファンラニン-5-カルボイル酸塩塩酸塩の主な用途は何ですか?
メチル(3R)-3-アミノ-2,3-ジヒドロ-1-ベンゾファンラニン-5-カルボイル酸塩塩酸塩は、医薬品や合成化学の研究に広く用いられます。また、特定の薬物の前...
トランス-4-メチルピロリジン-3-オール塩酸塩はどのように合成されますか?
トランス-4-メチルピロリジン-3-オール塩酸塩は、4-メチルピロリジンの塩酸塩化によって合成されます。一般的な合成方法では、4-メチルピロリジンを塩酸に加えて...
硫雜環丁烷-1,1-二氧化物は安全ですか?
硫雜環丁烷-1,1-二氧化物は安全ではありません。毒性は報告されていませんが、高温下で分解し、可燃性があるため、高圧ガスは注意が必要です。密閉した容器で保管し、...
9-ヒドロキシエリプチシネ塩酸塩はどのように合成されますか?
9-ヒドロキシエリプチシネ塩酸塩は、エリプチシネから塩酸を添加することで合成されます。選択性は高いですが、収率は約70%です。
5-塩素-2-(メチルアミノ)フェニル-(2-塩素フェニル)メタン酮の物理化学的性質は何ですか?
5-塩素-2-(メチルアミノ)フェニル-(2-塩素フェニル)メタン酮のCAS番号は5621-86-3です。この化合物は白色の結晶性粉末で、分子量は415.03で...
1-[2-(4-甲氧基-苯氧基)-乙基]-哌嗪はどのように保存すればよいですか?
1-[2-(4-甲氧基-苯氧基)-乙基]-哌嗪は、直射日光を避けて暗所に、室温(15-25℃)で保管し、密閉容器に入れることで安定性を保つことができます。
2-[3-(4-甲氧基フェニル)プロピル]-4,4,5,5-四メチル-1,3,2-ドイボロロールアンの主な用途は何ですか?
2-[3-(4-甲氧基フェニル)プロピル]-4,4,5,5-四メチル-1,3,2-ドイボロロールアンは、医薬品の合成、有機合成化学、および新材料の研究で使用され...
掲載誌
Analytical Methods

Analytical Methods welcomes early applications of new analytical and bioanalytical methods and technology demonstrating the potential for societal impact. We require that methods and technology reported in the journal are sufficiently innovative, robust, accurate, and compared to other available methods for the intended application. Developments with interdisciplinary approaches are particularly welcome. Systems should be proven with suitably complex and analytically challenging samples. We encourage developments within, but not limited to, the following technologies and applications: global health, point-of-care and molecular diagnostics biosensors and bioengineering drug development and pharmaceutical analysis applied microfluidics and nanotechnology omics studies, such as proteomics, metabolomics or glycomics environmental, agricultural and food science neuroscience biochemical and clinical analysis forensic analysis industrial process and method development

![N-[2-(4-Hydroxyphenoxy)-4-nitrophenyl]methanesulfonamide structure N-[2-(4-Hydroxyphenoxy)-4-nitrophenyl]methanesulfonamide structure](https://static.chemtradehub.com/structs/109/109032-22-6-7c88.webp)

![(2E)-3-(3-Chlorophenyl)-N-{2-[4-(methylsulfonyl)-1-piperazinyl]-2-oxoethyl}acrylamide structure (2E)-3-(3-Chlorophenyl)-N-{2-[4-(methylsulfonyl)-1-piperazinyl]-2-oxoethyl}acrylamide structure](https://static.chemtradehub.com/structs/250/2505001-54-5-c1e9.webp)
