l-Phenylalanine potassium catalyzed asymmetric formal [3 + 3] annulation of 2-enoyl-pyridine N-oxides with acetone

文献情報

出版日 2017-10-09

DOI 10.1039/C7QO00796E

インパクトファクター 5.281

著者

Youguo Xu, Sheng Zhang, Lijun Li, Yukang Wang, Zhenggen Zha, Zhiyong Wang

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要旨

A highly enantioselective formal [3 + 3] annulation of 2-enoyl-pyridine N-oxides with acetone was developed. In this transformation, an amino-acid salt L-phenylalanine potassium proved to be a robust organocatalyst, and the corresponding annulation derivatives can be obtained with moderate to excellent yields (up to 99%) and good to excellent enantioselectivities (up to 94%).

掲載誌

Organic Chemistry Frontiers

CiteScore: 7.8

自己引用率: 8.7%

年間論文数: 724

Organic Chemistry Frontiers publishes high-quality research from across organic chemistry. Emphases are placed on studies that make significant contributions to the field of organic chemistry by reporting either new or significantly improved protocols or methodologies. Topics include, but are not limited to the following: Organic synthesis Development of synthetic methodologies Catalysis Natural products Functional organic materials Supramolecular and macromolecular chemistry Physical and computational organic chemistry

l-Phenylalanine potassium catalyzed asymmetric formal [3 + 3] annulation of 2-enoyl-pyridine N-oxides with acetone

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