Pd/Ni catalyzed selective N–H/C–H methylation of amides by using peroxides as the methylating reagents via a radical process

文献情報

出版日 2017-08-15

DOI 10.1039/C7QO00625J

インパクトファクター 5.281

著者

Ze-lin Li, Chun Cai

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要旨

A palladium/nickel catalyzed selective N–H/C–H methylation of amides by using peroxides is described, providing N-methylation products and C-methylation products in moderate to good yields. In this procedure, peroxides play a dual role, serving as both the methyl source and radical initiator. This protocol tolerated a broad range of substrates, not only various sulfonamides but also methanamides. Mechanistic investigations involving a radical process are also described.

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Organic Chemistry Frontiers

CiteScore: 7.8

自己引用率: 8.7%

年間論文数: 724

Organic Chemistry Frontiers publishes high-quality research from across organic chemistry. Emphases are placed on studies that make significant contributions to the field of organic chemistry by reporting either new or significantly improved protocols or methodologies. Topics include, but are not limited to the following: Organic synthesis Development of synthetic methodologies Catalysis Natural products Functional organic materials Supramolecular and macromolecular chemistry Physical and computational organic chemistry

Pd/Ni catalyzed selective N–H/C–H methylation of amides by using peroxides as the methylating reagents via a radical process

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