Sodium nitrite-promoted aerobic oxidative coupling of aryl methyl ketones with ammonium under metal-free conditions: a facile access to polysubstitution imidazoles

文献情報

出版日 2017-05-02

DOI 10.1039/C7QO00247E

インパクトファクター 5.281

著者

Cheng-Kou Liu, Zhao Yang, Yu Zeng, Zheng Fang, Bo Li

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要旨

A practical, economic and efficient sodium nitrite-promoted aerobic oxidative synthesis of polysubstitution imidazoles from aryl methyl ketones has been developed. (4 or 5)-Aryl-2-aroyl-imidazoles are generated in good yields under metal-free conditions and in a one step process, which show highly potent antiproliferative activity. Based on some control experiments, a possible mechanism was proposed. Moreover, other multisubstituted heterocyclic derivatives, such as 1,2,4-trisubstituted imidazoles, were prepared under the sodium nitrite-promoted aerobic oxidative conditions.

掲載誌

Organic Chemistry Frontiers

CiteScore: 7.8

自己引用率: 8.7%

年間論文数: 724

Organic Chemistry Frontiers publishes high-quality research from across organic chemistry. Emphases are placed on studies that make significant contributions to the field of organic chemistry by reporting either new or significantly improved protocols or methodologies. Topics include, but are not limited to the following: Organic synthesis Development of synthetic methodologies Catalysis Natural products Functional organic materials Supramolecular and macromolecular chemistry Physical and computational organic chemistry

Sodium nitrite-promoted aerobic oxidative coupling of aryl methyl ketones with ammonium under metal-free conditions: a facile access to polysubstitution imidazoles

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