Study of thiol–ene chemistry on polymer brushes and application to surface patterning and protein adsorption

文献情報

出版日 2015-12-16

DOI 10.1039/C5PY01687H

インパクトファクター 5.582

著者

Khooi Y. Tan, Madeleine Ramstedt, Wilhelm T. S. Huck

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要旨

Polymer brushes are attractive polymeric coatings for biomedical applications such as tissue engineering, biosensor design and the purification of biological samples. In order to confer bioactivity to these coatings, their functionalisation with biomolecules, proteins and peptides, is required. In this respect, thiol–ene coupling offers interesting features as it is regioselective, efficient and can be controlled by photo-irradiation to allow surface patterning. The efficiency of thiol–ene and the related thiol–yne couplings to poly(glycidyl methacrylate) brushes was quantified. The impact of the structure of thiols to be tethered and reaction conditions on the brush loading and the kinetics of reaction were investigated. Thiol–ene reactions were then used to pattern brushes via direct irradiation through a mask or via reactive micro-contact printing. The resulting patterns were used to control albumin adsorption and the formation of protein patterns.

掲載誌

Polymer Chemistry

CiteScore: 8.6

自己引用率: 7.3%

年間論文数: 457

Polymer Chemistry welcomes submissions in all areas of polymer science that have a strong focus on macromolecular chemistry. Manuscripts may cover a broad range of fields, yet no direct application focus is required.

Study of thiol–ene chemistry on polymer brushes and application to surface patterning and protein adsorption

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