Heavy atom quenched coumarin probes for sensitive and selective detection of biothiols in living cells

文献情報

出版日 2015-05-01

DOI 10.1039/C5AN00549C

インパクトファクター 4.616

著者

Yuzhuo Ji, Qingqing Jin, Qingxiao Tong, Xinjing Tang

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要旨

A series of turn-on fluorescent probes with halogen acetyl amide at the 3-position of coumarin derivatives were synthesized. Fluorescence of these probes was efficiently quenched by heavy halogen atoms (Br and I, not Cl), which could be successfully used for selective detection of biothiols with the sensitivity of Cys > GSH > Hcy and much higher than thiol containing proteins. These represent the smallest fluorescence quenchers in designing fluorescent probes for detecting both endogenous and exogenous biothiols in living cells.

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Analyst

CiteScore: 7.8

自己引用率: 5.6%

年間論文数: 653

Analyst publishes analytical and bioanalytical research that reports premier fundamental discoveries and inventions, and the applications of those discoveries, unconfined by traditional discipline barriers.

Heavy atom quenched coumarin probes for sensitive and selective detection of biothiols in living cells

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