Catch and release: photocleavable cationic diblock copolymers as a potential platform for nucleic acid delivery

文献情報

出版日 2014-06-05

DOI 10.1039/C4PY00638K

インパクトファクター 5.582

著者

Matthew D. Green, Abbygail A. Foster, Chad T. Greco, Raghunath Roy, Rachel M. Lehr, Thomas H. Epps, III, Millicent O. Sullivan

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要旨

Binding interactions between DNA and cationic nanocarriers must be sufficiently strong to prevent nuclease-mediated degradation, yet weak enough to permit transcription. We demonstrate cationic diblock copolymers containing PEG and o-nitrobenzyl moieties that facilitated tailorable DNA complexation and light-activated release. This design unlocks a new approach to improved non-viral gene packaging.

掲載誌

Polymer Chemistry

CiteScore: 8.6

自己引用率: 7.3%

年間論文数: 457

Polymer Chemistry welcomes submissions in all areas of polymer science that have a strong focus on macromolecular chemistry. Manuscripts may cover a broad range of fields, yet no direct application focus is required.

Catch and release: photocleavable cationic diblock copolymers as a potential platform for nucleic acid delivery

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